| Comparative Hemodynamic and Structural Analysis of Normal, Stenotic, and Prolapsed Mitral Valves Using a Fully Coupled SPH FSI Framework |
| کد مقاله : 1005-CEC05 |
| نویسندگان |
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فاطمه میرزایی1، عطاالله کامیابی *2، علی محبی2 1ندارم 2ندارد |
| چکیده مقاله |
| Mitral valve pathologies such as stenosis and prolapse profoundly affect intracardiac hemodynamics and leaflet mechanics. In this study, a fully coupled fluid–structure interaction framework based on Smoothed Particle Hydrodynamics (SPH–FSI) was employed to comparatively investigate normal, stenotic, and prolapsed mitral valves using LS-DYNA. A unified valve geometry was adopted for all cases, and pathological conditions were introduced through systematic modifications of the leaflet material properties within an anisotropic hyperelastic formulation, allowing a direct assessment of stiffness-related mechanical effects. The normal valve exhibited a peak early-diastolic transvalvular flow rate of approximately 8 L/min. In the stenotic configuration, increased leaflet stiffness led to a reduction of peak forward flow by approximately 25% (to 6 L/min) and a prolonged deceleration phase. In contrast, the prolapsed model, characterized by reduced leaflet stiffness, showed an elevated early-diastolic flow (reaching 10–11 L/min) followed by a pronounced regurgitant phase, with peak reverse flow reaching approximately −20 L/min near valve closure. Analysis of leaflet stress revealed distinct mechanical signatures for each condition. Stenosis resulted in markedly elevated maximum principal stresses (peak 2200 kPa), particularly during valve opening and final closure (reaching over 2500 kPa), whereas prolapse exhibited substantially lower stress levels (peak 1000 kPa) throughout the cycle despite impaired coaptation. These results demonstrate that variations in leaflet material properties alone can reproduce key hemodynamic and structural features of mitral valve pathologies. The proposed SPH–FSI framework provides a robust computational tool for mechanistic comparison of mitral valve conditions and supports future patient-oriented valve assessment studies. |
| کلیدواژه ها |
| Mitral Valve, Stenosis, Prolapse, Fluid Structure Interaction (FSI), Smoothed Particle Hydrodynamics (SPH), Hemodynamics |
| وضعیت: پذیرفته شده مشروط |
